新兴应用质谱影像;推动者和路障|光谱学欧洲和世界半岛综合体育官方APP下载德甲bdapp官方下载安卓版

新兴应用质谱影像;推动者和路障

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MALDI-MS/MS image of longitudinally sectioned drug users’ hair samples (insert shows optical image of longitudinally sectioned hair). The image shows the differential distribution (quantities and location) of the product ion at m/z 182, derived from the precursor ion of cocaine at m/z 304 within the hair shaft of two cocaine users. The length of the analysed hair samples was 4 cm corresponding to a hair growth period of 4 month. Since the spatial resolution along the hair is 150 μm, each pixel is equivalent to approximately 12 h of growth (adapted and reproduced from https://doi.org/10.1007/s13361-017-1766-0 under a Creative Commons BY Licence).

质谱分析成像(MSI)是一个强大和灵活的技术能够调查多个非标签的内生和外生的空间分布分析物同时在一个广泛的样本。在过去的二十年里,MSI发现广泛应用广泛的学科包括临床前药物发现、临床应用和人类为法医鉴定的目的。仪器和软件功能的技术进步导致了MSI的兴趣不断增加;然而,仍有一些局限性。在这次审查中,我们讨论了新兴应用MSI显著影响质谱(MS)的三个关键领域research-clinical,临床前和法医及路障使用MSI在这些领域的扩张。

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c . Russo c·希顿l·弗林特o . Voloaca Haywood-Small,核磁共振握紧,s . Francese L.M.科尔,“新兴应用质谱影像;推动者和路障”,j .光谱成像9日,a13 (2020)。https://doi.org/10.1255/jsi.2020.a13

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